Wegovy
Injectable pen
Wegovy is a weekly self-injectable used for weight loss. It contains semaglutide, a medicine that helps control appetite and reduce food cravings.
Weight Loss Treatment Service
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Mounjaro
Injectable pen
Mounjaro is a weekly self–injectable pen used for weight loss. It contains tirzepatide which works by regulating blood sugar and energy balance levels, helping to reduce appetite and prevent cravings.
Wegovy
Tablets
A daily tablet used for weight loss. Contains semaglutide, the same medicine as Wegovy injections, to help control appetite and cravings.
Orlistat
Tablets
Orlistat (also available as branded Xenical) is a weight loss treatment that reduces how much fat is absorbed from food. It’s taken by mouth with meals.
Xenical
Tablets
Xenical is a brand name for Orlistat.
Everything you need to succeed
Our experts, in your pocket
Expert-led exercise videos, a podcast, webinars and more.
Ongoing care
1 year clinical support post-treatment, live webinars and help at 1,500+ Boots stores.
1-to-1 coaching
Discover our 360° coaching programme for results that last.
Track your progress
In our dedicated weight loss app,
on iOS and Android.
Exercise videos
Easy-to-follow exercise and movement routines from an expert team you can trust.
10-week programme
Expert guides and practical tips to support your weight loss journey, available in our freeTracker app.
Support from our clinical team throughout your journey, and for a year post-treatment.
Pharmacy help at 1,500+ Boots stores.
How it works
Find out how our service works, from the initial consultation to getting your treatment.
Consistency is key - 360° support for life
Weight loss treatment is most effective when used consistently alongside important lifestyle changes. That’s why we’ll stick by you so you can stick to reaching your goals with a range of free resources – from a podcast, live webinars and a 10-week programme, to exercise videos, 12 months of aftercare and a tracker app.
Pen or pill: which is right for you?
Learn more about the Wegovy Pill (oral semaglutide) and how to switch from the pen if you're thinking about it.
| Treatment | Mounjaro | Wegovy | Wegovy Pill | Xenical / Orlistat |
|---|---|---|---|---|
| Active ingredient | Tirzepatide | Semaglutide | Semaglutide | Orlistat |
| How much weight can I lose? | Average 22.5% after 18 months use(1) | Average 20.7% after 18 months use(2) | Average 16.6% after 16 months use(3) | Around 6% after a year's use(4) |
| How does it work? | Makes you feel fuller and reduces cravings by working on GLP-1 and GIP receptors | Makes you feel fuller and reduces cravings | Makes you feel fuller and reduces cravings | Reduces how much fat your body absorbs from food |
| Additional health benefits | Approved in the US for treating OSA (obstructive sleep apnoea) in people with obesity(5) | Approved in the UK to reduce the risk of serious heart issues (heart-related death, heart attacks, strokes) in adults with known heart disease(6) Approved in the US to treat MASH, a type of fatty liver disease with fibrosis (liver scarring)(7) |
Improvements in everyday activities like walking, bending and standing. Improvements in cholesterol levels and waist circumference. |
|
| How do I take it? | It's self-injected | It's self-injected | You take a daily tablet | You swallow a capsule |
| When do I take it? | Once a WEEK | Once a WEEK | Once a DAY, on an empty stomach with a small sip of water. You'll need to wait 30 mins before eating, drinking or taking other oral medicines. | Up to three times a day with meals |
| Does the dose change? | Dose increases every 4 weeks until you reach a maintenance dose(a) | Dose increases every 4 weeks until you reach a maintenance dose(a) | Dose increases every month until you reach a maintenance dose(a) | The dose stays the same, 1 capsule up to three times a day |
| Is it prescription only? | Yes | Yes | Yes | Yes |
| How long do I take it for? | As obesity is treated as a chronic condition, weight loss medicines can be taken long-term to help you reach a healthier weight. For long lasting weight loss you'll need to make some key lifestyle changes as well – we can help you with these. | |||
| How else can you help me? | 10-week weight loss support programme, live webinars and lots of helpful information on our website and in your patient record from our expert in-house Lifestyle Medicine team(b). Weight Loss Coaching for 1-to-1 guidance on nutrition, exercise and more(c). Weight Loss Tracker app to help you keep track of your progress(d). | |||
Approved by
Dr Anju Verma
GP and Weight Loss Service Clinical Lead
Read full bio
Last reviewed on 16/12/2025
Sources and references
Average weight loss clinical studies references. All patients also increased their physical activity and had a reduced calorie diet. Percentages taken from efficacy analyses.
Ania M. Jastreboff et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine. Available from https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 [Accessed 3 Jan 2024].
-Average weight loss of 22.5% at the 15mg dose at 72 weeks.
-Average weight loss of 21.4% at the 10 mg dose, and 16% at the 5mg dose at 72 weeks.
Wharton S et al. (2025). Once-weekly semaglutide 7·2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial. The Lancet Diabetes Endocrinology. Available from https://doi.org/10.1016/S2213-8587(25)00226-8 [Accessed 26 Feb 2026].
-Average weight loss of 20.7% at the 7.2mg dose at 72 weeks.
-Average weight loss of 17.5% at the 2.4mg dose at 72 weeks.
Wharton et al. (2025). Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity. Available from https://www.nejm.org/doi/10.1056/NEJMoa2500969 [Accessed 5 June 2026].
-Average weight loss of 16.6% at the 25mg dose at 64 weeks.
Pi-Sunyer X et al. (2015). A randomized, controlled trial of 3.0 mg of liraglutide in weight management. New England Journal of Medicine. Available from https://www.nejm.org/doi/full/10.1056/nejmoa1411892 [Accessed 31 March 2023].
-Average weight loss of 8% at the 3mg dose at 56 weeks.
Torgersen J et al. (2004). XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care. Available from https://diabetesjournals.org/care/article/27/1/155/26587/XENical-in-the-Prevention-of-Diabetes-in-Obese [Accessed 31 March 2023]
-Average weight loss of 6-8% with 120mg three times a day at 1 year.
Additional health benefits clinical studies references
Malhotra et al. (2024). Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity. New England Journal of Medicine [Accessed 20 Dec 24]
Ryan DH et al. (2024). Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial. Nature Medicine. Available from https://www.nature.com/articles/s41591-024-02996-7 [Accessed 23 Dec 2024]
Sanyal A et al. (2025). Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis. New England Journal of Medicine [Accessed 2 Mar 2026]
Additional support from Boots Online Doctor
(a)We'll let you know the dosing schedule in your personalised treatment plan.
(b)Available free to all Boots Online Doctor customers.
(c)Weight Loss Coach : get 1-to-1 coaching and nutritional advice for an additional fee.
(d)Weight Loss Tracker: our new app to help you track your weight and much more. Download from Apple and Google Play app stores.
| Ozempic | Rybelsus | |
| Active ingredient | Semaglutide | Semaglutide |
| Why don't you offer these? | Both these medicines are licensed for treating Type 2 diabetes. Limited supplies mean these medicines should be prioritised for patients with diabetes. | |
Being overweight — don't let it be a burden
Being overweight is a very common problem. More than 2/3 adults in the UK are either overweight or obese. Excess weight is linked to several serious health problems such as heart disease, diabetes and stroke.
We can prescribe medicine to help you to lose the extra weight — providing it's suitable for you. We'll get in touch with advice on how to best take your medicine and help you make the lifestyle changes you need to manage your weight over the long-term.
After you start any treatment we prescribe, we'll check in with you to see how you're getting on. If it's going well, you can potentially request repeat prescriptions for up to 12 months and we'll check in regularly with you to see if you are on track.
What is Mounjaro?
You might have been hearing quite a bit about Mounjaro (tirzepatide). This weight loss medicine has been available in the United States since 2022 for treating diabetes, and was approved in 2023 under the brand name Zepbound for use in weight management alongside a reduced calorie diet and increased physical activity. Mounjaro is now available in the UK with a prescription. An injection pen you need to use just once a week, Mounjaro helps to reduce appetite and curb cravings. It has performed well in clinical trials, with patients reported as experiencing significant weight loss.
Weight loss treatments and plans we offer
Learn more about weight loss managementGet the facts about losing weight from Dr Sarah
Learn more about healthy weight loss
Not sure how to check if you're a healthy weight for your height? Learn how to measure your BMI (Body Mass Index). Is your weight causing other medical problems?